The Mazziotti group pursues research in many-electron theory and computation to advance our ability to understand and predict molecular structure and processes.
Strongly Correlated Phenomenon
We study how entanglement drives energy transport and emergent behavior, revealing phenomena such as partial exciton condensation in biological and synthetic systems.
Electronic Structure Methods
We develop scalable methods that solve the electronic structure problem using the two-electron reduced density matrix, enabling accurate predictions in strongly correlated molecules and materials.
Quantum Computing
Our group designs quantum algorithms that leverage reduced density matrices to achieve efficient and accurate molecular simulations on current and future quantum computers.
Machine Learning
We use physics-informed machine learning to improve energy predictions, reduce many-electron problems to two-electron representations, and accelerate quantum algorithms.
Who We Are
We are dedicated to training graduate students, postdoctoral researchers, and undergraduates to tackle the grand scientific challenges of molecules and materials in chemistry and physics. Our group emphasizes close mentorship, individualized attention, and a collaborative environment that supports bold, transformative research. We value both collaboration among group members and partnerships with experimental teams across chemistry, physics, biology, and engineering. We are committed to preparing the next generation of leaders in academia, government, and industry through work that advances science and benefits society.
📰 Group News
New Graduates!
Anna Schouten and Samuel Warren received their Ph.D.s in Chemistry from the University of Chicago in June and July 2025, respectively. We congratulate them on their accomplishments and wish them continued success in their scientific careers!
Sweeping the Departmental Prizes
Irma Avdic received two awards recognizing her amazing work and outreach in the Chemistry Department and throughout the UChicago Community at the recent Chemistry Student Awards Assembly: The Albert J. Cross Prize for Excellence in Research, Teaching, and Departmental Citizenship and the Joan Shiu Chemistry Department Student Service Award.
Teaching Fellowship Awarded
Noah Garrett was awarded the highly coveted Chicago Center for Teaching and Learning (CCTL) Fellowship in recognition of his devotion to pedagogical studies!
NSF GRFP Winner!
Michael Rose was selected for the prestigious NSF Graduate Research Fellowship Program! We congratulate him and can’t wait to see what amazing work he accomplishes!
Imagination is more important than knowledge. Knowledge is limited. Imagination encircles the world.
Albert Einstein