The Development of Phosphodiesterase 4D Inihibitors with 3d Printing and Molecular Visualization Software for the Treatment of Acrodysostosis
By Emily D’Amato
Although scientists do not yet fully understand how memories are formed, a protein called phosphodiesterase 4D (PDE4D) is clearly involved. Some children are born with mutated, damaged PDE4D, which results in a genetic condition called acrodysostosis. Kids with acrodysostosis typically have learning disabilities as well as short fingers, short toes, narrow faces, and short height. Currently there is no treatment for acrodysostosis, but this research shows it may be possible to use a small molecule to help mutated PDE4D and treat acrodysostosis. These small molecules may also treat Alzheimer’s dementia, schizophrenia, depression, and Huntington’s disease3 …