Lysosomal Distribution in Distal Axons

Kevin Li

I specifically studied lysosomal distribution in distal axons, or the parts of the axons that were further away from the cell body. I did so using microfluidic chambers which are devices that allow the physical separation of the cell body and the axons . . . Altogether, my research actually suggests that lysosomes are mobile, and can be recruited to degrade waste in neurons axons, instead of staying within the neuronal cell body. Defects in lysosomal either transport or function may lead to accumulation of waste proteins in axons as seen in neuronal disorders. This study established a solid foundation to further investigate the role of lysosomes in distal axons under healthy and stress conditions associated with axonal degeneration. If we better understand the mechanisms behind lysosomal movement and distribution in axons, we can develop better therapeutic strategies in treating major neurodegenerative diseases, such as AD, PD, and ALS.